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COPPER-CATALYZED ELECTROPHILIC AMINATION OF SP2 AND SP3 C?H IBD

SPRINGER
08 / 2016
9783319388779
Inglés

Sinopse

This thesis reports the latest developments in the direct amination of various CâêÆH bonds using an HâêÆZn exchange/electrophilic amination strategy.á McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved CâêÆH zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonaldâÇÖs findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.á

PVP
133,14